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CYP3A4是细胞色素P450氧化酶家族成员之一。 这个家族中的若干其它成员也涉及到药物的代谢，但CYP3A4是最常见和最多面的一个。 CYP3A4 是人体内一种重要的 细胞色素P450酶，主要存在于 肝脏和小肠 中，负责代谢约 50%的临床常用药物，包括抗生素、抗癌药、降压药等。 细胞色素P450 3A4酶 (简称CYP3A4) (EC1.14.13.97)，是身体中的一种重要的酶，主要存在于肝脏和小肠。 它可以氧化外源有机小分子（异型生物质），如毒素或药物（包括降压药、抗生素、抗癌药等），以便使其排出体外。

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CYP3A4是CYP3A亚家族的主要成员，也是成人肝微粒体CYP450中最重要的成分，约占其总量的30%-40%，居第1位，甚至有的个体CYP3A4含量可达到P450总量的60%。 该酶主要表达在小肠、肝脏和肾脏。 CYP基因超家族的命名：以CYP开头，后面的阿拉伯数字表示基因家族，其后的大写英文字母表示亚家族，最后的阿拉伯数字表示某个CYP酶的基因编码，如CYP3A4。 舉例來說：葡萄柚汁是常見的酵素抑制劑（inhibitor），它會抑制CYP3A4肝臟酵素活性，而CYP3A4活性下降，代謝其他藥物（如：降血脂藥物）的能力下降，便會使降血脂藥物的血中濃度上升。

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Previously another cyp3a gene, cyp3a3, was thought to exist

However, it is now thought that this sequence represents a transcript variant of cyp3a4 Alternatively spliced transcript variants encoding different isoforms have been identified [provided by refseq, aug 2020] Cyp3a4 (cytochrome p450 family 3 subfamily a member 4) is a protein coding gene

Cytochrome p450 3a4 (abbreviated cyp3a4) (ec 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by cyp3a4 gene.